• Also known as Pulpy kidney/ over eating disease.
• Acute infectious toxemic disease of ruminant
• Characterized by diarrhea, convulsions, paralysis and sudden death.

a) Etiology:

• Clostridium perfringes type D-sheep

b) Transmission:

• Faeces or carcass of animal
• Ingestion of contaminated pasture in endemic areas

c) Pathogenesis:

• Changed diet—> change of bacteria population in rumen—->  increase in acid producing bacteria population—-> Decrease in pH Wound in rumen à proliferation of bacteria—> production of toxins à cause disease in animal.

d) Symptoms:

• Death of lambs within half to few hours
• Course of disease ( <2 hrs to never more than 12 hrs)
• Dull, depressed, anorectic, convulsion, salivation, diarrhea
• Glycosuria and hyperglycemia

e) Differential diagnosis:

• Black leg, Anthrax, Bloat, Pregnant toxemia, Acute poisoning

f) Diagnosis:

• History of overfeeding
• Demonstration of toxins
• Isolation and identification of organism